CD was preparing the manuscript of Variation for publication. He started working on it intermittently in 1860; from 16 November 1864 he had been revising the early chapters (see Correspondence vol. 12, Appendix II). In March 1865, he had written to Murray saying that he hoped the book would go to press in early autumn (see letter to John Murray, 31 March [1865]). CD agreed to Murray’s proposal to announce the work as a forthcoming publication, but warned that whether or not the book would, in fact, be ready by autumn would depend on his health (see letter from John Murray, 1 April 1865, and letter to John Murray, 4 April [1865] and n. 3).

See letter from John Murray, 1 April 1865, letter to John Murray, 4 April [1865], and letter from W. B. Tegetmeier to John Murray and R. F. Cooke, 17 April 1865.

Murray had advertised Variation in the Reader, 15 April 1865, p. 427 (see letter to John Murray, 31 March [1865] and n. 2). He advertised the book again in the 1 August 1865 issue of Publishers’ Circular, p. 386, under the title: ‘Domesticated Animals and Cultivated Plants, or the Principles of Variation, Inheritance, Reversion, Crossing, Interbreeding, and Selection under Domestication’.